師資陣容

兼任副教授

1. 台灣臨床細胞學會理事長
2. 衛福部與醫院評鑑暨醫療品質策進會聘任人體生物資料庫查核委員
3. TAF財團法人全國認證基金會-醫學領域技術委員
4. 戴德森醫療財團法人嘉義基督教醫院病理科/人體生物資料庫主任
5. Editorial board, Cancer Cytopathology (IF=5.284, 16/77 in Pathology)
6. Outreach editor, Cytopathology (IF: 2.073, 2020 ranking: 53/77 in Pathology)
7. Topic editor, Frontiers in Cell and Developmental Biology (IF=6.684, 2020 Rank= 6/41 in Developmental Biology)

成功大學臨床醫學研究所碩士(2014)
慈濟大學醫學系醫學士(2006)

【經歷】
成大醫院病理部住院醫師、總醫師、臨床導師 (2006-2010)
衛福部台南醫院主治醫師(2011-2012)

【研究專長】
Cancer biology, pathogen, cancer immunology, and cytopathology

1. 解剖病理專科醫師;
2. 細胞病理指導醫師；
3. 能力試驗執行機構認證規範ISO/IEC 17043：2010訓練通過。

國際細胞學會院士 (Fellow of International Academy of Cytology)

To study the role of autophagy-regulated secretion of galectin-1 by tumor-associated macrophages in sorafenib resistance of hepatocellular carcinoma. Co-PI, CYCH-IRB106030, 2018.08.01-2021.07.30 (the National fund number: 107-2320-B-006-026 -MY3, NT. 3,900,000)

https://www.researchgate.net/profile/Chien-Chin-Chen-2/research

1. Kao YS, Wang LC, Chang PC, Lin HM, Lin YS, Yu CY, Chen CC, Lin CF, Yeh TM, Wan SW, Wang JR, Ho TS, Chu CC, Zhang BC, Chang CP. Negative regulation of type I interferon signaling by integrin-linked kinase permits dengue virus replication. PLoS Pathog. 2023 Mar;19(3):e1011241. doi: 10.1371/journal.ppat.1011241. (IF: 7.464, 2021 Rank=25/137, MICROBIOLOGY)(Original article)

2. Hong ZB, Lai YT, Chen CH, Chen YJ, Chen CC*, Lin WC*. Trichomonas tenax induces barrier defects and modulates inflammatory cytotoxicity in gingival and pulmonary epithelial cells. Parasite 2023 Mar;30:7. doi: 10.1051/parasite/2023010. (IF: 3.020, 2021 Rank=16/39, PARASITOLOGY)(Original article)(Co-corresponding author)

3. Ahmad I, Alotaibi BS, Malak N, Asad F, Ullah B, Nasreen N, Khan A, Chen CC*. Antidiarrheal potential of viola canescens: in vivo and in silico approaches. Pharmaceuticals Pharmaceuticals. 2023 March; 16(4):489. doi:10.3390/ph16040489. (IF: 5.215, 2021 Rank=69/279, PHARMACOLOGY & PHARMACY)(Original article)(Corresponding author)

4. Li SH, Chiou CC, Chen CC*. The reduced expression of trimethylation of histone H3 at lysine 27 in primary cutaneous mucinous carcinoma. Dermatol Sin Accepted on Feb 12 2023. (IF: 1.107, 2021 Rank=64/69, DERMATOLOGY)(Brief report)(Corresponding author)

5. Wu CL, Chang SW, Lee YY, Chen TY, Chen CC, Chu CB, Medeiros LJ, Chang KC. Distribution and clinical features of lymphomas involving skin in Taiwan. Kaohsiung J Med Sci. 2023;10.1002/kjm2.12659. doi:10.1002/kjm2.12659. (IF: 2.996, 2021 Rank=97/139, MEDICINE, RESEARCH & EXPERIMENTAL)(Original article)

6. Chen PC, Yeh YM, Chu CT, Su PF, Chiu PH, Lin BW, Chen SH, Lin PC, Lee CT, Chen HW, Chen CC*. HER2 amplification in colorectal cancer with brain metastasis: a propensity score matching study. Eur J Cancer. 2023 Mar;181:62-69. doi:10.1016/j.ejca.2022.12.019 (IF: 10.002, 2021 Rank=31/245, ONCOLOGY)(Original article)(Corresponding author)

7. Jhang JF, Liu CD, Hsu YH, Chen CC, Chen HC, Jiang YH, Wu WC, Peng CW, Kuo HC. EBV infection mediated BDNF expression is associated with bladder inflammation in interstitial cystitis/bladder pain syndrome with Hunner’s lesion. J Pathol. 2023 Mar;259(3):276-290. (IF: 9.883, 2021 Rank=4/77, Pathology)(Original article)

8. Saman S, Chen CC, Malak N, Khan A, Nasreen N, Khan A, Niaz S, Rehman G, Rodriguez-Vivas RI, Cossío-Bayúgar R. Ethanolic extracts of Datura innoxia have promising acaricidal activity against rhipicephalus microplus as it blocks the glutathione s-transferase activity of the target tick. Genes. Genes 2023, 14(1), 118. (IF: 4.141, 2021 Rank=72/175, GENETICS & HEREDITY)(Original article)(Co-1st author)

9. Huang LT, Kuo CH, Tseng L, Li YS, Cheng LH, Cheng CY, Sheu SR, Chang WT, Chen CC, Cheng HC. Alpha-mangostin reduces pericellular fibronectin on suspended tumor cells and therapeutically, but not prophylactically, suppresses distant metastasis. Life (Basel). 2022 Sep;12(9):1375. (IF: 3.251, 2021 Rank=39/94, Biology)(Original article)

10. Wu WF, Shen CW, Lai KM, Chen YJ, Lin EC, Chen CC*. The Application of DTCWT on MRI-Derived Radiomics for Differentiation of Glioblastoma and Solitary Brain Metastases. J. Pers. Med. 2022, 12, 1276. (IF: 3.508, 2021 Rank=69/172, Medicine, General & Internal)(Original article)(Corresponding author)

11. Lee YY, Hwang TZ, Jin YT, Chen CC*. Sclerosing microcystic adenocarcinoma arising from the tongue: a case report and literature review. Diagnostics (Basel). 2022 May;12(5):1288. (IF: 3.992, 2021 Rank=60/172, Medicine, General & Internal)(Case report)(Corresponding author)

12. Lai KM, Wang JH, Lin SC, Wen Y, Wu CL, Su JH, Chen CC*, Lin CC. Crassolide Induces G2/M cell cycle arrest, apoptosis, and autophagy in human lung cancer cells via ROS-mediated ER stress pathways. Int J Mol Sci. 2022 May; 23(10):5624. (IF: 6.208, 2021 Rank=69/296, Biochemistry & Molecular biology)(Original article)(Corresponding author)

13. Kuo WT, Chang JM, Chen CC, Tsao N, Chang CP. Autophagy drives plasticity and functional polarization of tumor-associated macrophages. IUBMB Life. 2022 Jan; 74(2):157-169. (IF: 4.709, 2021 Rank=125/296, Biochemistry & Molecular Biology)(Review article)

14. CY Hu, KY Wu, TY Lin, CC Chen*. The crosstalk of long non-coding RNA and microRNA in castration-resistant and neuroendocrine prostate cancer: their interaction and clinical importance. Int. J. Mol. Sci. 2022, 23(1), 392. (IF: 6.208, 2021 Rank=69/296, Biochemistry & Molecular biology) (Review article)(Corresponding author)

15. Lee WJ, Chen CC*. Adult inclusion conjunctivitis diagnosed by polymerase chain reaction and giemsa stain. IDCases. 2022, 27, e01367. (ESCI journal)(Case report)(Corresponding author)

16. Thingujam B, Syue LS, Wang RC, Chen CJ, Yu SC, Chen CC, Medeiros LJ, Liao IC, Tsai JW, Chang KC. Morphologic Spectrum of lymphadenopathy in adult-onset immunodeficiency (anti-interferon-γ autoantibodies). Am J Surg Pathol. 2021 Nov; 45(11):1561-1572. (IF: 6.298, 2021 Rank=10/77, Pathology) (Original article)

17. Wu CY, Wu JD, Chen CC*. The Association of Ovarian Teratoma and Anti-N-Methyl-D-Aspartate Receptor Encephalitis: An Updated Integrative Review. Int. J. Mol. Sci. 2021 Oct; 22(20):10911. (IF: 6.208, 2021 Rank=69/296, Biochemistry & Molecular biology) (Review article)(Corresponding author)

18. Kuo CT, Chen CC. Biomimetic wax interfaces facilitating rehealable polymer composites. Polymers (Basel). 2021 Sep; 13(18):3052. (IF: 4.967, 2021 Rank=16/90, Polymer Science) (Original article)(Co-1st author)

19. Davuluri GV, Chen CC, Chiu YC, Tsai HW, Chiu HC, Chen YL, Tsai PJ, Kuo WT, Tsao N, Lin YS, Chang CP. Autophagy drives galectin-1 secretion from tumor-associated macrophages facilitating hepatocellular carcinoma progression. Front. Cell Dev. Biol. 2021 Sep; 9:741820. (IF: 6.081, 2021 Rank=6/39, Developmental Biology)(Original article) (Co-1st author)

20. Liu CY, Chen CC, Bychkov A, Agarwal S, Zhu Y, Hang JF, Lai CR, Na HY, Li W, Liu Z, Jain D, Suzuki A, Hirokawa M, Chia N, Nga ME, Jitpasutham T, Keelawat S, Park SY, Satoh S, Gunawardena D, Kumarasinghe P, Jung CK, Kakudo K. Constitutive cytomorphologic features of medullary thyroid carcinoma using different staining methods. Diagnostics (Basel). 2021 Aug; 11(8):1396. (IF: 3.992, 2021 Rank=60/172, Medicine, General & Internal) (Original article) (Co-1st author)

21. Kuk M, Kuo CJ, Nguyen VH, Chen CC*. Synchronous thyrolipoma and papillary thyroid carcinoma: a rare but significant event. Diagnostics (Basel). 2021 Jul;11(8):1334. (IF: 3.992, 2021 Rank=60/172, Medicine, General & Internal) (case report) (Corresponding author)

22. Lin YH, Lin YC, Chen CC*. Lysophosphatidic Acid Receptor Antagonists and Cancer: The Current Trends, Clinical Implications, and Trials. Cells. 2021 Jun; 10(7):1629. (IF: 7.666, 2021 Rank=51/194, Cell biology)(Review article) (Corresponding author)

23. Wu YH, Huang YF, Chang TH, Chen CC, Wu PY, Huang SC. COL11A1 activates cancer-associated fibroblasts by modulating TGF-β3 through the NF-κB/IGFBP2 axis in ovarian cancer cells. Oncogene. 2021 Jul;40(26):4503-4519. (IF: 8.756, 2021 Rank=40/296, Biochemistry & Molecular Biology) (Original article)

24. Lin CH, Hsia K, Su CK, Chen CC, Yeh CC, Ma H, Lu JH. Sonication-Assisted Method for Decellularization of Human Umbilical Artery for Small-Caliber Vascular Tissue Engineering. Polymers (Basel). 2021 May; 13(11):1699. (IF: 4.967, 2021 Rank=16/90, Polymer Science) (Original article)

25. Wu KJ, Li SH, Liao JB, Chiou CC, Wu CS, Chen CC*. NRAS mutations may be involved in the pathogenesis of cutaneous Rosai Dorfman disease: a pilot study. Biology (Basel). 2021 May; 10(5):396. (IF: 5.168, 2021 Rank=21/94, Biology) (Original article) (Corresponding author)

26. Yang HY, Tu CW, Chen CC, Lee CY, Hsu YC. Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience. Breast Cancer Res. 2021 Apr;23(1):43. (IF: 8.408, 2021 Rank=43/245, Oncology) (Original article)

27. Wang JC, Li WS, Kao YC, Lee JC, Lee PH, Huang SC, Tsai JW, Chen CC, Chang CD, Yu SC, Huang HY. Clinicopathologic and molecular characterization of USP6-rearranged soft tissue neoplasms: The evidence of genetic relatedness indicates an expanding family with variable bone-forming capacity. Histopathology. 2021 Apr;78(5):676-689. (IF: 7.778, 2021 Rank=7/77, Pathology) (Original article)

1. Chen CC, Tung CL, Jin YT, Wu CL, Chan John KC. (2018, Apr) Epithelioid sialohamartoma of the parotid gland in an infant with tuberous sclerosis. Presentation at HKIAP Spring Scientific Meeting 2018, Hongkong, China.

2. Huang ZY, Chen CC. (2018, May) Anastomosing hemangioma: the first case report in nasal cavity. Presentation at the 2018 IAP-Taiwan annual meeting, Taipei, Taiwan.

3. Chen CC. (2018, May). A retrospective case study of pleural effusion lymphomas from a Taiwanese medical institute. Presentation at the 59th annual spring meeting of the Japanese Society of Clinical Cytology, Sapporo, Japan.

4. Chen CC. (2018, Oct). Ovarian benign stromal tumors: a 23-year retrospective cohort study of 79 cases from Taiwan with clinicopathological analyses. Presentation at the 22nd Taiwan-Japan-Korea Joint Meeting for Gynecological Pathology.

5. Chen CC. (2019, Jan). My path to cytology: from outsider to insider. Invited to talk, presented at the 26th Thai-Japanese Workshop in Diagnostic Cytopathology, Bangkok, Thailand.

6. Chen CC. (2019, May). Elevated CA-125 and Ascites are not uncommon in ovarian benign stromal tumours: a retrospective cohort study of 79 cases with clinicpathological analyses. Best ePoster in Gynecology, presented at the 20th International Congress of Cytology, Sydney, Australia.

7. Chen CC. (2019, Jun). HHV-8 negative effusion-based lymphomas express mature B-cell immunophenotype. Presentation at the 60th annual spring meeting of the Japanese Society of Clinical Cytology, Tokyo, Japan.

8. Chen CC. (2019, Oct). How to interpret thyroid FNA: my easy-to-follow steps. Invited to talk, presented at the 12th Pathology Conference of South Vietnam, Ho Chih Min city, Vietnam.

9. Chen CC. (2020, Nov). The biosafety of cytopatholgy and practical impacts in Asia-Pacific region in the covid-19 pandemic. Invited to talk, presented at the webinar conference of Finnish Society for Clinical Cytology.

10. Chen CC. (2021, Apr). 1) The 2020 International System for Reporting Serous Fluid Cytopathology;2)The overview of Milan system for reporting salivary gland cytopathology. Invited to talk, presented at the webinar conference, the Pathology Master Class Series, Season 2, of IAP-Thailand Association.

11. Chen CC. (2021, Oct). COVID-19 and its impacts on cytopathology. Chairman and invited to talk, presented at the companion session of Taiwan, the 43rd European Congress of Cytology, Wrocław, Poland.

12. Chen CC. (2022, April). Common Diagnostic Pitfalls in Thyroid Cytology. Invited to talk, presented at the online science meeting of the Ho Chi Minh City Society of Pathology in HCMC, Vietnam.

13. Chen CC. (2022, July). The Common Pitfalls in Thyroid FNAs When Establishing Our Diagnostic Pipelines. Invited to talk, presented at the 12th Annual Siriraj-Johns Hopkins Cytopathology Course, Bangkok, Thailand.

14. Chen CC. (2022, Dec). The Role of Tumor-Associated Macrophage in Hepatocellular Carcinoma. Invited to talk, presented at the 4th Taiwan Epigenomics Symposium and International Conference on Biotechnology and Healthcare, Chiayi, Taiwan.

Thyroid FNA Cytology - Differential Diagnoses and Pitfalls 3rd ed. 2023 Edition. Chapter 13: International Comparison Study of Thyroid Fine Needle Aspiration (FNA) Cytology Reporting System. (chapter editors: Chiung-Ru Lai, and Chien-Chin Chen)