師資陣容

教授兼系主任、研究所所長

教授

高雄醫學大學藥學所博士

【經歷】
1. 嘉南藥理大學 助理教授、副教授
2. 新莊醫院 藥師

【研究專長】
1. 中草藥化妝品原料開發
2. 中草藥萃取、純化及結構之鑑定

1. 藥師證書
2. 化粧品安全資料簽署人員 合格
3. 生技化粧保養品研發管理師
4. 經絡健康管理師
5. IAA芳療師
6. APTF頭皮管理師

1. 榮獲2014年台灣創新技術博覽會發明競賽 銀牌獎
2. 榮獲2014年台灣創新技術博覽會發明競賽 銅牌獎
3. 榮獲2016年台灣創新技術博覽會發明競賽 銀牌獎

1. 以生物轉化與生物活性雙重導向進行中藥經人體代謝後有效成份之研究，科技部，(114/08/01～117/07/31)，共同主持人
2. 以結合資料庫之導向性生物轉化合成新型生物活性分子，科技部，(114/08/01～117/07/31)，共同主持人
3. 產學合作計畫－資料庫探勘技術搭配醣水解酶與黃酮磷酸合成酶自中藥成份開發新活性分子，(114/06/01～115/05/31)，共同主持人
4. 以BBGP生物轉化平台開發新型活性分子，科技部，(113/08/01～114/07/31)，共同主持人
5. 產學合作計畫－結合資料庫探勘與生物轉化自中藥成份中開發新藥效分子，科技部，(113/06/01～114/05/3)，共同主持人
6. 以生物轉化製備新穎萜類與類黃酮醣苷分子之酵素催化平台，(112/08/01～113/11/30) ，共同主持人
7. 產學合作計畫－內生性靈芝皂苷生產之研究，科技部，(112/06/01～113/05/31)，共同主持人
8. 以醣水解酶生產靈芝皂苷與多醣皂苷之研究，科技部，(2022/08/01~2025/07/31 )，共同主持人
9. 三萜與黃酮類分子醣苷化生成新型皂苷之研究，科技部，(2022/08/01~2023/07/31)，共同主持人
10. 靈芝皂苷之生產與生物活性研究，科技部，(2021/08/01~2022/07/31)，共同主持人
11. 粉團蓼萃取及功效研究，產學，(2019/04/01~2019/10/31)，主持人
12. 異黃酮多酚糖苷的生產與生物活性研究，科技部，(2018/06/01~2019/05/31)，共同主持人
13. 紅藜/嗜熱鏈球菌/蔬莓果酵素產品之功效性評估，產學，(2017/10/01~2018/10/31)，共同主持人

1. Chien-Yu Wu, Jiumn-Yih Wu, Muddasir Khan, Hsiou-Yu Ding, Tzi-Yuan Wang, Hui-Ling Huang, Yi-Xuan Li and Te-Sheng Chang (2025) Biotransformation; a novel approach for the production of 6-hydroxyluteolin 7-O-methylglucuronide compound with antioxidant and anti-inflammatory potential. Nat. Prod. Res., https://doi.org/10.1080/14786419.2025.2536633
2. Te-Sheng Chang, Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wangd, Guan-Cheng Liu, Min-Lin Wang and Huei-Ju Ting (2025) Enzymatic synthesis of a new and bioactive dihydrochalcone: 3,4-dihydroxy-2',6'-dimethoxy dihydrochalcone. Nat. Prod. Res., 8, 1-12. https://doi.org/10.1080/14786419.2025.2500079
3. Te-Sheng Chang, Hsiou-Yu Ding, Tzi-Yuan Wang, Jiumn-Yih Wu, Po-Wei Tsai, KhyleS. Suratos, LemmuelL.Tayo, Guan-Cheng Liu and Huei-Ju Ting, (2025) In silico-guided synthesis of a new, highly soluble, and anti-melanoma flavone glucoside: Skullcapflavone II-6′-O-β-glucoside. Biotechnol. Appl. Biochem., 72 (3), 621-637. https://doi.org/10.1080/10826068.2025.2585924
4. Chien-Yu Wu, Jiumn-Yih Wu, Muddasir Khan, Hsiou-Yu Ding, Tzi-Yuan Wang, Hui-Ling Huang, Yi-Xuan Li and Te-Sheng Chang, (2025) Synthesis of a novel bioactive compound by biotransformation of 4-[(2',4'-Dinitrophenyl)amino]-phenol (DPAP) via predicted data mining approach (PDMA). Biocatal. Biotransformation, 43, 334-343. https://doi.org/10.1080/10242422.2025.2503247
5. Te-Sheng Chang, Jiumn-Yih Wu, Hsiou-Yu Ding and Tzi-Yuan Wang, (2025) Enzymatic glycosylation of Ganoderma terpenoid via bacterial glycosyltransferases and glycoside hydrolases. Biomolecules, 15, 655-671.
https://doi.org/10.3390/biom15050655
6. Te-Sheng Chang, Jiumn-Yih Wu, Hsiou-Yu Ding, Lemmuel L. Tayo, Khyle S. Suratos, Po-Wei Tsai, Tzi-Yuan Wang, Yu-Ning Fong and Huei-Ju Ting, (2025) Predictive production of a new highly soluble glucoside, corylin-7-O-β-glucoside with potent anti-inflammatory and anti-melanoma activities. Appl. Biochem. Biotech., 197 (2), 1174-1191. https://doi.org/10.1007/s12010-024-05071-6
7. Te-Sheng Chang, Hsiou-Yu Ding, Jiumn-Yih Wu, Chuan-Che Lee, Ziting Yang, Yu-Chuan Liu and Tzi-Yuan Wang, (2025) New methyl compounds using the predicted data mining approach (PDMA), coupled with the biotransformation of Streptomyces peucetius O-methyltransferase, Biocatal. Biotransformation, 43 (1), 84-96. https://doi.org/10.1080/10242422.2024.2406906
8. Chien-Yu Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Chun-Wei Liu, Jiumn-Yih Wu and Te-Sheng Chang, (2024) Glycosylation of 6-gingerol and unusual spontaneous deglucosylation of two novel intermediates to form 6-shogaol-4′-O-β-glucoside by bacterial glycosyltransferase. Appl. Environ. Microbiol., 90 (10).
https://doi.org/10.1128/aem.00779-24
9. Chien-Yu Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Chun-Wei Liu, Jiumn-Yih Wu,Te-Sheng Chang, (2024) Development of a new isoxsuprine hydrochloride-based hydroxylated compound with potent antioxidant and anti-inflammatory activities. J. Microbiol. Biotechnol., 34(12), 2693–2701.
https://doi.org/10.4014/jmb.2405.05031
10. Te-Sheng Chang, Jiumn-Yih Wu, Hsiou-Yu Ding, Han-Ying Lin, Tzi-Yuan Wang, (2024) Exploring gingerol glucosides with enhanced anti-inflammatory activity through a newly identified α-glucosidase (ArG) from Agrobacterium radiobacter DSM 30147, Journal of Bioscience and Bioengineering, 138, 218-224.
11. Te-Sheng Chang, Hsiou-Yu Ding, Jiumn-Yih Wu, Min-Lin Wang, and Huei-Ju Ting, (2024) Biotransformation-guided purification of a novel glycoside derived from the extracts of Chinese herb Baizhi, Journal of Bioscience and Bioengineering, 137, 47-53.
12. Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Min-Hui Hsu and Te-Sheng Chang, (2023) A New Stilbene Glucoside from Biotransformation-Guided Purification of Chinese Herb Ha-Soo-Oh, plants, 11, 2286.
13. Hsiou-Yu Ding, Tzi-Yuan Wang, Jiumn-Yih Wu, Yun-Rong Zhang, and Te-Sheng Chang, (2023) Novel Ganoderma triterpenoid saponins from the biotransformation-guided purification of a commercial Ganoderma extract, Journal of Bioscience and Bioengineering, 135, 402-410.
14. Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Cheng-Zhi Cai, Te-Sheng Chang, (2023) Antioxidant and anti-α-glucosidase activities of biotransformable dragon’s blood via predicted data mining approach, Process Biochemistry, 130, 166-173.
15. Jiumn-Yih Wu, Hsiou-Yu Ding, Shun-Yuan Luo, Tzi-Yuan Wang , Yu-Li Tsai and Te-Sheng Chang, (2022) Novel Glycosylation by Amylosucrase to Produce Glycoside Anomers, biology, 11, 822.
16. Jiumn-Yih Wu, Tzi-Yuan Wang, Hsiou-Yu Ding, Chuan-Che Lee and Te-Sheng Chang, (2022) A Novel Soy Isoflavone Derivative, 30-Hydroxyglycitin, with Potent Antioxidant and Anti-a-Glucosidase Activity, plants, 11, 2202.
17. Jiumn‐Yih Wu, Hsiou‐Yu Ding, Tzi‐Yuan Wang, Cheng‐Zhi Cai and Te‐Sheng Chang, (2022). Application of Biotransformation‐Guided Purification in Chinese Medicine: An Example to Produce Butin from Licorice, Catalysts, 12, 718.
18. Hsiou-Yu Ding, Tzi-Yuan Wang, Jiumn-Yih Wu, Yu-Li Tsai and Te-Sheng Chang, (2022). Enzymatic Synthesis of Novel and Highly Soluble Puerarin Glucoside by Deinococcus geothermalis Amylosucrase, Molecules, 27 (13), 4074.
19. Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Yu-Li Tsai, Huei-Ju Ting and Te-Sheng Chang, (2021). Improving Aqueous Solubility of Natural Antioxidant Mangiferin through Glycosylation by Maltogenic Amylase from Parageobacillus galactosidasius DSM 18751. Antioxidants, 10, 1817-1833.
20. Jiumn-Yih Wu, Tzi-Yuan Wang, Hsiou-Yu Ding, Yun-Rong Zhang, Shu-Yuan Lin and Te-Sheng Chang (2021). Enzymatic Synthesis of Novel Vitexin Glucosides. Molecules, 26, 6274-6284.
21. Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Yun-Rong Zhang and Te-Sheng Chang, (2021). International Journal of Molecular Sciences. Glycosylation of Ganoderic Acid G by Bacillus Glycosyltransferases, 22, 9744-9752.
22. Chen-Liang Chao, Hui-Chi Huang, Hsiou-Yu Ding, Jenn-Haung Lai, Hang-Ching Lin, Wen-Liang Chang (2019). A new macrocyclic diterpenoid from Anisomeles indica. Natural Product Research, 34 (19), 2737-2745.
23. Leong-Perng Chana, Ya-Ping Tseng, Hsiou-Yu Ding, Sheng-Ming Pan, Feng-Yu Chiang, Ling-Feng Wang, Tzung-Han Chou, Pei-Jung Lien, Cheng Liuh, Po-Lin Kuoa, Chia-Hua Liang (2019). Tris(8-Hydroxyquinoline)iron induces apoptotic cell death via oxidative stress and by activating death receptor signaling pathway in human head and neck carcinoma cells. Phytomedicine, 63, 1-14.
24. Pei-Shan Wu, Hsiou-Yu Ding, Jui-Hung Yen, Shu-Fen Chen, Kuan-Han Lee, Ming-Jiuan Wu (2018). Anti-inflammatory Activity of 8-Hydroxydaidzein in LPS-Stimulated BV2 Microglial Cells via Activation of Nrf2-Antioxidant and Attenuation of Akt/NF-κB-Inflammatory Signaling Pathways, as Well As Inhibition of COX-2 Activity. J. Agric. Food Chem., 66 (23), 5790-5801.
25. Chien-Min Chiang, Hsiou-Yu Ding, Jing-Yu Lu, Te-Sheng Chang (2016). Biotransformation of isoflavones daidzein and genistein by recombinant Pichia pastoris expressing membrane-anchoring and reductase fusion chimeric CYP105D7. Journal o fthe TaiwanInstitute of ChemicalEngineers, 60, 26-31.
26. Hsiou-Yu Ding, Pei-Shan Wu and Ming-Jiuan Wu (2016). Cleome rutidosperma and Euphorbia thymifolia Suppress Inflammatory Response via Upregulation of Phase II Enzymes and Modulation of NF-B and JNK Activation in LPS-Stimulated BV2 Microglia. International Journal of Molecular Sciences, 17(9).
27. Chien-Min Chiang, Hsiou-Yu Ding, Ya-Ting Tsai and Te-Sheng Chang (2016). Production of Two Novel Methoxy-Isoflavones from Biotransformation of 8-Hydroxydaidzein by Recombinant Escherichia coli Expressing O-Methyltransferase SpOMT2884 from Streptomyces peucetius. International Journal of Molecular Sciences, 16, 27816-27823.
28. Shih-Hao Wang, Chia-Hua Liang, Fong-Pin Liang, Hsiou-Yu Ding, Shiuan-Pey Lin, Guan-Jhong Huang, Wen-Chuan Lin and Shin-Hun Juang (2016). The inhibitory mechanisms study of 5,6,4’-trihydroxy-7,3’-dimethoxyflavone against the LPS-induced macrophage inflammatory responses. Molecules. 21, 136-148.

1. Yu-Li Tsai, Jiumn-Yih Wu, Te-Sheng Chang, Tzi-Yuan Wang and Hsiou-Yu Ding, Using Biotransformation-guided Purification to Produce New Ganoderma SaponinsUsing Biotransformation-guided Purification to Produce New Ganoderma Saponins, 2023, 第28屆台灣生物技術暨生化工程 (BEST) 國際研討會暨Symposium of Young Asian Biological Engineers' Community (YABEC)
2. Te-Sheng Chang, Yu-Li Tsai, and Hsiou-Yu Ding, Transglycosylation Activity of a New Maltogenic Amylase, 2022, 第37屆天然物研討會Nature is the Best Guide 暨李國雄院士紀念會法道自然
3. Hsiou-Yu Ding, Jiumn-Yih Wu, Tzi-Yuan Wang, and Te-Sheng Chang, Using Copper-Containing Tyrosinase to Produce 3’-Hydroxyglycitein, 2022, 10th Asian Biological Inorganic Chemistry (AsBIC10)
4. 林伊庭，丁秀玉，Etermity-柚享恆妍，2022美粧產學論壇暨永續發展國際研討會
5. 陳又瑄，丁秀玉，Herb’s Life 好髮無傷，2022美粧產學論壇暨永續發展國際研討會
6. 杜浩維，丁秀玉，Natural Skin-抗痘植萃之開發，2022美粧產學論壇暨永續發展國際研討會
7. 李韋儒，丁秀玉，柚子與七種常見的中草藥抗氧化及美白功效評估，2022美粧產學論壇暨永續發展國際研討會
8. Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Yun-Rong Zhang and Te-Sheng Chang, Ganoderma Saponins from Biotransformation of Ganoderic Acid G, 2021 TwIChE 台灣化學工程學會68週年年會 暨科技部化學工程學門成果發表會/前瞻分子工程研討會
9. Hsiou-Yu Ding, Wan-Jung Cheng andZi-You Huang, Plant extracts and the potential beneficial effects in antioxidant, anti-inflammatory, and anti-tyrosinase activities, 2020 International Cosmetic-Tech Conference & Exhibition.
10. Hsiou-Yu Ding, Leong-Perng Chan, Ya-Ping Tseng, Ting-Hong Tsai1, Chia-Hua Liang, 8-Hydroxyquinoline derivatives induces apoptic cell death via oxidative stress changes in skin cancers, 2019 International Conference on Pharmaceutical & Cosmetic Sciences and Health Biotechnology (ICPCH 2019).
11. Chen-Cong Wei, Hsiou-Yu Ding, Pei-Yu Wu, Pin-Ju Chen, Chia-Hua Liang, Anti-inflammatory and reduction of lipid accumulation of Oregon's product development. 2018 The 30th International Competition for Cosmetic, Hairdressing, and Nail Painting Techniques of 2018.
12. 鄭琬榕，丁秀玉，皺子白花菜之抗發炎在醫美保養品之開發，2018 The 30th International Competition for Cosmetic, Hairdressing, and Nail Painting Techniques of 2018.
13. 吳文慈，丁秀玉，中草藥萃取物在抗菌與抗氧化之開發，2018 The 30th International Competition for Cosmetic, Hairdressing, and Nail Painting Techniques of 2018.
14. 陳怡瑄，許珮蓉，蕭珮聿，李詩凡，李姵妍，郭保辰，丁秀玉，草本在唇部彩妝中之應用，2017 The 29th International Competition for Cosmetic, Hairdressing, and Nail Painting Techniques of 2017.
15. 黃語絜，陳喬筠，黃以琳，盧宇潔，黃玉燕，吳佩玲，丁秀玉，煥采新肌，2017 The 29th International Competition for Cosmetic, Hairdressing, and Nail Painting Techniques of 2017.
16. 吳佩諭，陳素貞，曾雅萍，丁秀玉，陳品儒，梁家華，黃金初乳抑制活性氧及促穀胱甘肽活性之探討及功效性保養品開發，2017 The 29th International Competition for Cosmetic, Hairdressing, and Nail Painting Techniques of 2017.
17. Hsiou-Yu Ding, Paeonia suffruticosa for applicationof skin whiteness and antioxidation，2017 International Cosmetic-Tech Conference & Exhibition.

美容藥粧學
天然中草藥化粧品學
APTF頭皮管理

【專利】
1. 吳俊毅，丁秀玉，王子元，馮毓甯，張德生，丁慧如，(2025) 新型葡萄糖苷化合物及其用途，中華民國證書號數：I875246
2. 吳俊毅，丁秀玉，王子元，蔡雨利，張德生，丁慧如，(2024)芒果苷醣苷及其製備方法，中華民國證書號數：I837950
3. 吳俊毅，丁秀玉，王子元，李權哲，張德生，(2023)羥基黃豆黃苷用途，中華民國證書號數：I813507
4. 吳俊毅，丁秀玉，王子元，蔡承志，張德生，(2023)羥基龍血素、其生產方法與用途，中華民國證書號數：I812448
5. 張德生，吳俊毅，丁秀玉，王子元，蔡雨利，張芸蓉，蔡承志，(2023)靈芝酸糖苷變旋異構物及其生產方法，中華民國證書號數：I800179
6. 吳明娟，丁秀玉，吳佩珊，(2021)作為Nrf 2促效劑之大豆異黃酮衍生物及含此之組成物暨其應用，專利字號: I722299
7. 郭玫君，吳明娟，丁秀玉，邱贊瑋，張繼隆，張凱裕 ，曾允立，(2021)大黃萃取物及其用於製備抑制皮屑芽孢菌生物膜組成物之用途，專利字號: I722282
8. 郭玫君，丁秀玉，吳明娟，張繼隆，邱贊瑋，鄭玲莉，(2019)植物萃取物用於製備抑制白色念珠菌生物膜組成物之用途，專利字號: I679017
9. 丁秀玉，吳明娟，吳佩珊，李曼伯，蘇意婷，(2019)皺子白花菜萃取物用於製備抗神經發炎之組合物之用途，專利字號: I677344
10. 吳明娟，丁秀玉，吳佩珊，李曼伯，蘇意婷，(2019)千根草萃取物用於製備抗神經發炎之組合物之用途，專利字號: I652063
11. 郭玫君，吳明娟，丁秀玉，梁碩容，呂宜蓁，洪子娘，李佳勳，(2018)杭荊芥萃取物及其用於製備抑制皮屑芽孢菌與白色念珠菌組成物之用途，專利字號: I626055
12. 丁秀玉，梁家華，周宗翰 ，曾良鵬，(2018)川續斷萃取物用於製備抑制氧化作用達到皮膚抗老化之組成物的用途，專利字號: I624265
13. 丁秀玉，梁家華，周宗翰 ，陳品儒，(2017)牛至萃取物用於製備抗氧化之組成物之用途，專利字號: I606836
14. 張德生，蔡雅婷，丁秀玉，江建民，(2017)甲氧異黃酮的生物轉換製備方法與用途，專利字號: I580784
15. 郭玫君，丁秀玉，吳明娟，謝佩珊，莊才峰，林靖黌，趙仕堯，吳佩珊，(2017)紅茄綠果醇類萃取區分物用於製備兼具抑菌及抑制黑色素生成的外用組成物之用途，專利字號: I564017
16. 梁家華，丁秀玉，周宗翰 ，(2016)用於抑制皮膚黑色素生成之3-羥基-4-甲氧基苯甲酸，專利字號: I562785
17. 丁秀玉，張德生，江建民，(2016)製備鄰位-羥基異黃酮的方法，專利字號: I545198
18. 梁家華，丁秀玉，周宗翰 ，(2016)蠶絲蛋白於製備促進膠原蛋白生成之組成物之用途，專利字號: I543774
19. 吳明娟，丁秀玉，王麗淑，王慧温，顏福村，(2016)紅茄萃取物用於製備抗發炎之組成物之用途，專利字號: I543766
20. 吳明娟，丁秀玉，郭玫君，邱淑媛，蔡月夏，葉倪君，王慧温， (2016)到手香萃取物於製備改善痤瘡之組成物之用途，專利字號: I535449